Not generally, no!! Well... it depends on what is 'small' dunnit. I tend to conceptualize a lot of ideas on a theme all at once and pitch them all on one big canvas, sometimes making that canvas bigger or smaller along the way. The individual drawings will be quite small often, but I'm workshopping a whole set of them, discarding and adding willy-nilly.

That said I overall much prefer to work in small sizes with a 1px brush or at most, 6px or something. So generally nothing gets very 'large' in the, like, '300dpi print size' sense! For instance, my various DELTARUNE pieces recently made, were all conceptualized at once on a canvas about 8,000px x 5,000px. That includes all of the references, thumbnails, of around 10 pieces I was conceptualizing (not all were finished). The final individual images when cut out were more like 600px x 500px.

My SPLATOON pieces were all on one canvas around 5,000px x 1,000px. One of the final images cut from it is around 500px x 500px.

I tend to thumbnail a bunch of things at once, then ink everything at once, etc, so even if it will eventually be 10 discreet individual images, they often start out on the same canvas. I have a habit of completing things in 'batches'...

I tend to like a lot of 'gutters', excess room all around to 'cut out' and move things around in, if I want to re-draw a portion of a drawing or take another whack at it, I want to just duplicate the chunk and keep it on retainer on the canvas, while I redraw it. So everything always has all of this scrap nonsense floating around the actual drawing. The very last thing I do is crop all of this nonsense out. My work often has 'frames' around drawings because this is just the most useful way to remember what I'm constraining things to, to remember the borders I'm imagining....